Indolent Adult T-Cell Leukemia Lymphoma

Indolent adult T-cell leukemia-lymphoma is a kind of leukemia diseases that almost make the patient died after get this diseases. Based on the research on Adult T-cell leukemia-lymphoma (ATL) from 1974 to 2003, newly diagnosed indolent ATL in 90 patient (65 chronic type and 25 smoldering type), 12 patient remained alive for more than 10 years, 44 progressed to acute ATL and 63 patient died. These findings suggest that even patient with indolent ATL should be carefully observed in clinical practice.

 

Adult T-cell leukemia Lymphoma (ATL) is a peripheral T-lymphocytic malignancy associated with human T-cell lumphotropica virus type 1 (HTLV-1). ATL has been classified into 4 clinical subtype acute: Lymphoma, chronic, and smoldering. In general, acute and lymphoma types of ATL have an extremely poor prognosis despite advance in chemotherapy and allogenic hematopoietic stem cell transplantation because of multidrug resistance, a large tumor burden with multiorgan failure, hypercalcemia, and frequent infection complication associated wit a T-Cell immunodeficiency.